TargetRanger
TargetRanger
Systematic target prioritization for TCGA subtypes with TargetRanger
Each cancer type from TCGA was analyzed to identify subtypes from the RNA-seq samples with unsupervised clustering. Samples from each clusters can be submitted to TargetRanger for analysis. Information about each cluster is provided near each interactive UMAP plot.
Adrenocortical carcinoma (ACC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Bladder Urothelial Carcinoma (BLCA)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Breast invasive carcinoma (BRCA)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Cholangiocarcinoma (CHOL)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Colorectal adenocarcinoma (COADREAD)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Colon adenocarcinoma (COAD)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Esophageal carcinoma (ESCA)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
(GBMLGG)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Glioblastoma multiforme (GBM)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Head and Neck squamous cell carcinoma (HNSC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Kidney Chromophobe (KICH)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Kidney renal clear cell carcinoma (KIRC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Kidney renal papillary cell carcinoma (KIRP)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Acute Myeloid Leukemia (LAML)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Brain Lower Grade Glioma (LGG)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Liver hepatocellular carcinoma (LIHC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Lung adenocarcinoma (LUAD)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Lung squamous cell carcinoma (LUSC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Mesothelioma (MESO)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Ovarian serous cystadenocarcinoma (OV)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Pancreatic adenocarcinoma (PAAD)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Pheochromocytoma and Paraganglioma (PCPG)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Prostate adenocarcinoma (PRAD)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Rectum adenocarcinoma (READ)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Sarcoma (SARC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Skin Cutaneous Melanoma (SKCM)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Stomach adenocarcinoma (STAD)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Stomach and Esophageal carcinoma (STES)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Testicular Germ Cell Tumors (TGCT)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Thyroid carcinoma (THCA)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Thymoma (THYM)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Uterine Corpus Endometrial Carcinoma (UCEC)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Uterine Carcinosarcoma (UCS)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
Uveal Melanoma (UVM)
Top cell-surface targets for each subtype. Rows are tumor subtypes determined by the Leiden algorithm. Columns are the top significant (adjusted p-value < .01) targets identified by TargetRanger, sorted by frequency across subtypes and filtered for targets identified using the ARCHS4, GTEx, and Tabula Sapiens atlases as backgrounds.
